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Research
Summary
Cornea
and External Disease
Mathematical modeling of infectious diseases.
The World Health Organization (WHO) recommends mass administration
of single-dose oral antibiotics in trachoma endemic areas. However
it is not clear how often mass treatment should be administered. Clinical
trials may provide useful information, but will take years to complete
and may be prohibitively expensive. We are using mathematical models
to determine the frequency of mass drug administration necessary to
eliminate trachoma. |
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Trachoma
community treatment strategies.
There is increasing evidence that mass oral antibiotic treatment may
be effective against endemic trachoma. However, because of the expense
of treatment, the risk of side-effects, and the emergence of resistance
(e.g. streptococcal resistance to macrolides), it will be important
to limit the use of antibiotics to only that which is necessary. We
conduct clinical trials in western Nepal to determine the optimal
way to distribute antibiotics in a community. |
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